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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HMGCS1
All Species:
41.82
Human Site:
T125
Identified Species:
61.33
UniProt:
Q01581
Number Species:
15
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q01581
NP_001091742.1
520
57294
T125
T
D
I
E
G
I
D
T
T
N
A
C
Y
G
G
Chimpanzee
Pan troglodytes
XP_517780
610
66491
T215
T
D
I
E
G
I
D
T
T
N
A
C
Y
G
G
Rhesus Macaque
Macaca mulatta
XP_001090857
592
65050
T197
T
D
I
E
G
I
D
T
T
N
A
C
Y
G
G
Dog
Lupus familis
XP_536483
637
69021
T242
T
D
I
E
G
I
D
T
T
N
A
C
Y
G
G
Cat
Felis silvestris
Mouse
Mus musculus
Q8JZK9
520
57550
T125
T
D
I
E
G
I
D
T
T
N
A
C
Y
G
G
Rat
Rattus norvegicus
P17425
520
57415
T125
T
D
I
E
G
I
D
T
T
N
A
C
Y
G
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506375
520
57160
T125
T
D
I
E
G
I
D
T
T
N
A
C
Y
G
G
Chicken
Gallus gallus
P23228
522
57541
T125
T
D
V
E
G
I
D
T
T
N
A
C
Y
G
G
Frog
Xenopus laevis
NP_001087380
520
57303
T125
T
D
V
E
G
I
D
T
T
N
A
C
Y
G
G
Zebra Danio
Brachydanio rerio
NP_957379
508
55918
G121
T
T
N
A
C
Y
G
G
T
A
A
L
F
N
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_524711
465
51158
V90
E
V
G
T
E
T
I
V
D
K
S
K
S
V
K
Honey Bee
Apis mellifera
XP_397202
453
50855
R78
I
K
P
E
D
I
G
R
L
E
V
G
T
E
T
Nematode Worm
Caenorhab. elegans
P54871
462
51397
C86
I
S
T
D
S
I
G
C
L
V
V
G
T
E
T
Sea Urchin
Strong. purpuratus
XP_801879
508
56054
T126
T
D
L
E
G
I
D
T
T
N
A
C
Y
G
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P54873
461
51076
I86
E
V
G
S
E
T
V
I
D
K
S
K
S
I
K
Baker's Yeast
Sacchar. cerevisiae
P54839
491
54995
T116
I
K
S
Y
N
I
D
T
N
K
I
G
R
L
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
85
87.3
78.6
N.A.
94.6
94.8
N.A.
90.1
83.9
80
77.6
N.A.
58
54.6
38.4
63.2
Protein Similarity:
100
85
87.3
80.5
N.A.
97.5
97.6
N.A.
95.3
91
88.6
87.1
N.A.
69.6
68.6
54.8
75.3
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
100
93.3
93.3
20
N.A.
0
13.3
6.6
93.3
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
100
100
26.6
N.A.
6.6
13.3
13.3
100
Percent
Protein Identity:
N.A.
N.A.
N.A.
44
45.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
60.1
60.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
6.6
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
7
0
0
0
0
0
7
69
0
0
0
7
% A
% Cys:
0
0
0
0
7
0
0
7
0
0
0
63
0
0
0
% C
% Asp:
0
63
0
7
7
0
69
0
13
0
0
0
0
0
0
% D
% Glu:
13
0
0
69
13
0
0
0
0
7
0
0
0
13
7
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% F
% Gly:
0
0
13
0
63
0
19
7
0
0
0
19
0
63
63
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
19
0
44
0
0
82
7
7
0
0
7
0
0
7
0
% I
% Lys:
0
13
0
0
0
0
0
0
0
19
0
13
0
0
13
% K
% Leu:
0
0
7
0
0
0
0
0
13
0
0
7
0
7
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
7
0
7
0
0
0
7
63
0
0
0
7
0
% N
% Pro:
0
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
7
0
0
0
0
7
0
0
% R
% Ser:
0
7
7
7
7
0
0
0
0
0
13
0
13
0
0
% S
% Thr:
69
7
7
7
0
13
0
69
69
0
0
0
13
0
13
% T
% Val:
0
13
13
0
0
0
7
7
0
7
13
0
0
7
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
7
0
7
0
0
0
0
0
0
63
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _